Use of COVID-19 Vaccines in the United States

At a glance

• These clinical considerations inform healthcare professionals and public health officials on use of COVID-19 vaccines.
• The Table of Contents on each page can be used to navigate to all guidance pages.
• A PDF version of the complete clinical considerations is available below to download and print.

Table of Contents | Interim Clinical Considerations

1. COVID-19 Vaccines and Vaccination
2. Routine COVID-19 Vaccination Guidance
3. People Who Are Immunocompromised
4. Implementation Guidance
5. Contraindications and Precautions
6. Safety Considerations for COVID-19 Vaccines
7. Reporting Adverse Events
8. Special Situations and Populations
9. Appendix: Vaccine Administration Errors and Deviations
10. References and Previous Updates

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Summary of recent changes

Last updated May 1, 2025

• The Interim Clinical Considerations have been divided into multiple pages by guidance topic to enhance usability.
• Vaccination guidance and schedules are unchanged; some text has been reformatted and reorganized.